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3-[(Diethoxyphosphoryl)oxy]-1-methylquinolinium methyl sulfate
3D model (JSmol)
|Molar mass||407.37 g·mol−1|
|Main hazards||Extremely toxic|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|20 μg/kg (mice, intravenous)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD50 is 20 μg/kg in mice. It is over 300 times more potent than neostigmine.
- HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. PMC 1509437. PMID 13172424.
- Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.
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