After three seasons of minor league baseball, Wine made his major league debut on September 2, 1986 as a September call-up. He played nine games, getting 3 hits in 12 at bats.
In 1987, Wine was called up again in July after both Mark Bailey and Ronn Reynolds had been tried as the backup catcher to Alan Ashby. Wine played in 13 games in July and August, but batted just .103. He appeared in one final major league game on October 3. The following spring, he was traded to the Texas Rangers for pitcherMike Loynd, and from 1988-90 he played in five different organizations without returning to the majors.
After his playing career ended following the 1990 season, Wine served as an assistant coach in professional baseball from 1991–1996. Prior to the 1997 season, he accepted an assistant coaching position at his alma mater Oklahoma State. Prior to the 2005 season, he was hired as the head baseball coach at Penn State. Following the 2013 season, he resigned the position. His career record was 228-262.
National champion Postseason invitational champion Conference regular season champion Conference regular season and conference tournament champion Division regular season champion Division regular season and conference tournament champion Conference tournament champion
^"Robbie Wine". AstrosDaily.com. Archived from the original on 2012-06-27. Retrieved 27 June 2012. Drafted eighth overall in 1983 out of Oklahoma State, the son of big leaguer Bobby Wine was supposed to be the answer for Houston's catching woes but Robbie had trouble cracking the lineup in the majors.