Roger L. Williams
Roger Williams at the Royal Society admissions day in London, July 2017
|Born||Roger Lee Williams|
University of Cambridge|
Laboratory of Molecular Biology
Boris Kidrič Institute, Belgrade
|Thesis||The Structures of Two Ribonuclease B containing Crystals (1986)|
Roger Lee Williams FRS FMedSci is a structural biologist and group leader at the Medical Research Council (MRC) Laboratory of Molecular Biology. His group studies the form and flexibility of protein complexes that associate with and modify lipid cell membranes. His work concerns the biochemistry, structures and dynamics of these key enzyme complexes.
Williams was educated at Purdue University (BS) and Eastern Washington University (MS). He completed his PhD at the University of California, Riverside in 1986 for research investigating the structure of ribonuclease.
Research and career
The work of Williams group is deciphering mechanisms of activation and inhibition of diverse members of the phosphoinositide 3-kinase (PI3K) enzyme a family of enzymes involved in cell-cell communication, lysosomal sorting, nutrient sensing, cell proliferation and DNA-damage response. Mutations in PI3K signalling pathways are common in human tumours, and the William lab focuses on how they contribute to oncogenesis and how pharmaceuticals can specifically target these pathways. The Williams group has shown how conformational changes in the p110 alpha isoform accompanies its activation on cell membranes, and established that oncogenic mutations activate PI3Ks by mimicking or enhancing these conformational changes. His group is uncovering structural and dynamic features that dictate the extreme sensitivity of PI3K complexes to membrane lipid packing and membrane curvature.
His research has funded by Cancer Research UK, the Medical Research Council, AstraZeneca, the Biotechnology and Biological Sciences Research Council (BBSRC), the Wellcome Trust, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of General Medical Sciences and the British Heart Foundation.
Awards and honours
Williams is a member of European Molecular Biology Organization and Fellow of the Academy of Medical Sciences (FMedSci). He was awarded the Morton Lectureship by the Biochemical Society[when?] and was elected a Fellow of the Royal Society (FRS) in 2017.
- Roger L. Williams publications indexed by Google Scholar
- Roger L. Williams's Entry at ORCID
- Anon (2017). Williams, Dr Roger. ukwhoswho.com. Who's Who (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.289310. (subscription required)
- Anon (2017). "Dr Roger Williams FRS". royalsociety.org. London: Royal Society. Archived from the original on 2017-05-05. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 2016-11-11. Retrieved 2016-03-09.
- Roger L. Williams publications indexed by the Scopus bibliographic database. (subscription required)
- Roger L. Williams publications from Europe PubMed Central
- Williams, Roger Lee (1986). The structures of two ribonuclease B. containing crystals. proquest.com (PhD thesis). University of California, Riverside. OCLC 15004961.
- Walker, Edward H.; Pacold, Michael E.; Perisic, Olga; Stephens, Len; Hawkins, Philip T.; Wymann, Matthias P.; Williams, Roger L. (2000). "Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine". Molecular Cell. 6 (4): 909–919. doi:10.1016/s1097-2765(05)00089-4. PMID 11090628.