Rogletimide

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Rogletimide
Rogletimide.svg
Identifiers
CAS Number 121840-95-7
PubChem (CID) 56487
ChemSpider 50963
UNII 14P4QR28QF YesY
Chemical and physical data
Formula C12H14N2O2
Molar mass 218.25 g/mol
3D model (Jmol) Interactive image

Rogletimide is a drug related in chemical structure to the sedative glutethimide, but instead having pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide, but with no significant sedative effect.[1] This makes it potentially useful in the treatment of some forms of cancer, and with less side effects than aminoglutethimide, but its lower potency caused it to be unsuccessful in clinical trials.[2]

References[edit]

  1. ^ Vanden Bossche HV, Moereels H, Koymans LM (1994). "Aromatase inhibitors--mechanisms for non-steroidal inhibitors". Breast Cancer Research and Treatment. 30 (1): 43–55. doi:10.1007/bf00682740. PMID 7949204. 
  2. ^ MacNeill FA, Jones AL, Jacobs S, Lønning PE, Powles TJ, Dowsett M (October 1992). "The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer". British Journal of Cancer. 66 (4): 692–7. doi:10.1038/bjc.1992.339. PMC 1977412Freely accessible. PMID 1419608.