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Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
ATCvet code
Legal status
Legal status
  • Veterinary use only
  • N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.158.065 Edit this at Wikidata
Chemical and physical data
Molar mass258.094 g·mol−1
3D model (JSmol)
  • C1CN=C(N1)NC2=C(C=CC=C2Br)F
  • InChI=1S/C9H9BrFN3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) ☒N
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Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses,[1] although it may be used in a wide variety of species.[2][3] It is not used in humans, but is closely related in structure to the commonly used drug clonidine.

Romifidine acts as an agonist at the α2 adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol.[4][5] Yohimbine can be used as an antidote to rapidly reverse the effects.


  1. ^ Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U (November 2005). "Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses". American Journal of Veterinary Research. 66 (11): 1992–8. doi:10.2460/ajvr.2005.66.1992. PMID 16334961.
  2. ^ De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI (February 2007). "Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine". Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine. 54 (1): 48–50. doi:10.1111/j.1439-0442.2007.00910.x. PMID 17359455.
  3. ^ Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A (January 2008). "Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats". The Veterinary Record. 162 (3): 82–7. doi:10.1136/vr.162.3.82. PMID 18204032. S2CID 41300654.
  4. ^ Corletto F, Raisis AA, Brearley JC (January 2005). "Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies". Veterinary Anaesthesia and Analgesia. 32 (1): 16–22. doi:10.1111/j.1467-2995.2004.00184.x. PMID 15663735.
  5. ^ Kerr CL, McDonell WN, Young SS (October 2004). "Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse". Canadian Journal of Veterinary Research. 68 (4): 274–82. PMC 1111358. PMID 15581222.