Born in 1958 to German parents in Melbourne, Australia, Ron Mueck grew up in the family business of puppetry and doll-making. He worked initially as a creative director in Australian children’s television, before moving to America to work there in film and advertising. In 1996, he was asked by Paula Rego to make a small figure of Pinocchio for her group exhibition Spellbound: Art and Film, at the Hayward Gallery, London.
Mueck first came to public attention with his sculpture "Dead Dad". This portrayal of his recently deceased father - at roughly half-scale  and made from memory and imagination - was included in the 1997 exhibition Sensation at the Royal Academy of Arts, London.
Mueck’s first solo show was at the Anthony d’Offay Gallery, London in 1998. His 5-metre (16 ft) high sculpture Boy 1999 was a feature in the Millennium Dome, and later exhibited at the 49th Venice Biennale in 2001. Today it sits in the foyer of the Danish Contemporary Art Museum ARoS in Aarhus.
Between 2000 and 2002, Mueck was Associate Artist at the National Gallery, London. During this two-year post he created the works Mother and Child, Pregnant Woman, Man in a Boat, and Swaddled Baby and culminated in an exhibition in 2003.
Mueck’s most recent major touring exhibition began at Fondation Cartier pour l'Art Contemporain (Paris), in 2013, and travelled to Fundacion Proa, Buenos Aires., MAM, Rio de Janeiro  (marking the biggest audience in the history of that museum), and São Paulo, exhibited at the Pinacoteca.
During 2016, Mueck exhibited at the Theseus Temple, Kunsthistorisches Museum, Vienna, and Sara Hildén Art Museum, Finland.
In 2017 Mueck had a major solo presentation at the Museum of Fine Arts, Houston. As part of the Hull City Of Culture, Mueck's works appeared as part of SKIN, at the Ferens Art Gallery (Hull, UK), alongside paintings by Lucien Freud and Edouard Manet, and Spencer Tunick's photographs of his installation Sea Of Hull. The exhibition features a new work Poke, as well as Wild Man, Spooning Couple, Youth, Ghost, and Mask II.
Mueck's sculpture responds to the minute details of the human body, playing with scale to produce engrossing visual images (a style known as hyperrealism). Mueck spends a long time, sometimes more than a year, creating each sculpture. His subject matter is deeply private, and is often concerned with people’s unspoken thoughts and feelings.
- Duane Hanson
- George Segal
- John De Andrea
- Carole Feuerman
- Patricia Piccinini
- Zharko Basheski
- Roman sculpture (historical connection)
- Ron Mueck: From Muppets to motherhood | Art and design | The Guardian
- Hurlston, David; et al. (2011). Ron Mueck (Exhibition Catalog). Melbourne: Yale University Press in association with National Gallery Victoria. p. 20. ISBN 978-0-300-17683-4.
- Hurlston, David; et al. (2011). Ron Mueck (Exhibition Catalog). Melbourne: Yale University Press in association with National Gallery Victoria. p. 9. ISBN 978-0-300-17683-4.
- Greeves, Susanna; Colin Wiggins (2003). Ron Mueck. London: National Gallery Company. pp. 23–41. ISBN 1-85709-167-1.
- Ron Mueck in Fundación Proa, Buenos Aires
- Ron Mueck in MAM-Museum of Modern Art, Rio de Janeiro Archived 5 July 2014 at the Wayback Machine.
- Ruan Mueck exhibition achieves record attendance at MAM
- Ron Mueck in Pinacoteca do Estado de São Paulo Archived 29 November 2014 at the Wayback Machine.