The first Rosario derby was played on June 18, 1905, it resulted in a 1-0 win for Newell's Old Boys with a goal from Faustino González.
The clubs continued to play each other in the "Liga Rosarina de Fútbol" for many years. In 1939 the two clubs were admitted to the Argentine Primera, the first game at this level resulted in a 1-1 draw on June 18, 1939.
Experts claim that the Mexican Monterrey derby holds similarities with the Rosario derby. The teams are crosstown rivals from cities away from the capital and have very passionate fans.
The teams nicknames relate from the same incident where Rosario Central refused to play a charity game for a Leprosy charity, hence their nickname Canallas (Scoundrels). Newell's Old Boys stepped in to play the game and earned the nickname Los Leprosos (The Lepers).
August 2, 1908: Won 9-3 in the highest scoring derby, with 5 goals from Corti.
May 25, 1914: Harry Hayes scored a hat-trick to help Rosario Central win 6-2, starting a run of 11 consecutive wins.
October 17, 1915: Won 0-6 to record their best ever away win in the fixture.
June 29, 1916: Won 8-0 in a qualifier for the Copa de Honor.
1917: Won 9-0 to record the biggest ever win in the official's derby fixture.
December 19, 1971: Won 1-0 in the semi-final of the Nacional championship. Then, finally Central was the Argentine Champion.
April 11, 1975: Won 1-0 in a Copa Libertadores playoff to eliminate Newell's and progress to the 2nd round.
1980: Won 3:1 in the aggregate in the semi-final of the National Championship. It was 3:0 at home and 0:1 at Newell's stadium. Then, as in 1971, Rosario Central won the final, and was the Argentina's champion again.
August 29, 2005: Won 1-0 in the second leg of a Copa Sudamericana preliminary round, to progress 1-0 on aggregate.