Rosterolone

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Rosterolone
Rosterolone.svg
Clinical data
Routes of
administration
Topical
Identifiers
Synonyms 17α-Propylmesterolone; 17β-Hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.071.904
Chemical and physical data
Formula C23H38O2
Molar mass 346.54662 g/mol
3D model (JSmol)

Rosterolone (INN) (developmental code name SH-434), also known as 17α-propylmesterolone or 1α-methyl-17α-propyl-5α-androstan-17β-ol-3-one, is a steroidal antiandrogen that was first reported in 1984 and was developed for topical administration but was never marketed.[1][2][1] It has shown some efficacy in the treatment of acne, and in animal models lacks systemic effects with topical application.[1][2] Rosterolone is a derivative of mesterolone, which, in contrast, is an androgen and anabolic steroid.[3]

See also[edit]

References[edit]

  1. ^ a b c Luderschmidt, Christoph; Eiermann, Wolfgang; Jawny, Johannes; Bidlingmaier, Frank; Ring, Johannes (1984). "17?-Propylmesterolone (SH 434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations". Naunyn-Schmiedeberg's Archives of Pharmacology. 328 (2): 214–218. ISSN 0028-1298. doi:10.1007/BF00512076. 
  2. ^ a b Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. ISSN 0929-8673. PMID 10637363. doi:10.2174/0929867003375371. 
  3. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 775–. ISBN 978-1-4757-2085-3.