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SNP: rs1805054
Name(s) C267T, 267T/C
Gene HTR6
Chromosome 1
External databases
Ensembl Human SNPView
dbSNP 1805054
HapMap 1805054
SNPedia 1805054
HgenetInfoDB 1805054
AlzGene Meta-analysis

In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene. It is one of the few investigated polymorphisms of its gene. C267T is a synonymous polymorphism.

As of 2008 meta-analysis of the polymorphism and Alzheimer's disease indicates that there probably is no association between the two,[1] though individual studies report such an association, e.g., a Chinese study found an association with late-onset Alzheimer's disease.[2] Another reported association in neuropsychiatry disorders is with treatment response in depression.[3]

C267T has also been examined in relation to personality traits, with a Korean study finding some evidence for an association with the trait self-transcendence.[4] A Japanese study reported no association with personality traits using the NEO PI-R personality inventory.[5]


  1. ^ "META-ANALYSIS OF ALL PUBLISHED AD ASSOCIATION STUDIES (CASE-CONTROL ONLY) rs1805054". Alzheimer Research Forum. Archived from the original on 2013-02-25. Retrieved 2008-07-04. 
  2. ^ Rui Kan, Binbin Wang, Chuanfang Zhang, Ze Yang, Shun Ji, Zeping Lu, Chenguang Zheng, Feng Jin & Li Wang (November 2004). "Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese". Neuroscience Letters. 372 (1): 27–29. doi:10.1016/j.neulet.2004.09.007. PMID 15531082. 
  3. ^ Seung-Hwan Lee, Kang-Joon Lee, Heon-Jeong Lee, Byung-Joo Ham, Seung-Ho Ryu & Min-Soo Lee (April 2005). "Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder". Psychiatry and Clinical Neurosciences. 59 (2): 140–145. doi:10.1111/j.1440-1819.2005.01348.x. PMID 15823158. 
  4. ^ Byung-Joo Ham, Yong-Ho Kim, Myung-Jin Choi, Ji-Hyun Cha, Yun-Kyeung Choi & Min-Soo Lee (January 2004). "Serotonergic genes and personality traits in the Korean population". Neuroscience Letters. 354 (1): 2–5. doi:10.1016/S0304-3940(03)00753-5. PMID 14698468. 
  5. ^ Mamoru Tochigi, Hiroyuki Hibino, Takeshi Otowa, Toshiyuki Ohtani, Takashi Ebisawa, Nobumasa Kato & Tsukasa Sasaki (July 2006). "No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population". Neuroscience Letters. 403 (1–2): 100–102. doi:10.1016/j.neulet.2006.04.020. PMID 16682118.