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RsmY RNA family

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RsmY RNA family
Identifiers
SymbolRsmY
RfamRF00195
Other data
RNA typeGene; sRNA
Domain(s)Bacteria
SOSO:0000655
PDB structuresPDBe

The rsmY RNA family is a set of related non-coding RNA genes, that like RsmZ, is regulated by the GacS/GacA signal transduction system in the plant-beneficial soil bacterium and biocontrol model organism Pseudomonas fluorescens CHA0. GacA/GacS target genes are translationally repressed by the small RNA binding protein RsmA. RsmY and RsmZ RNAs bind RsmA to relieve this repression and so enhance secondary metabolism and biocontrol traits.[1]

Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins LetA and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor.[2]

See also

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References

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  1. ^ Valverde C, Heeb S, Keel C, Haas D (November 2003). "RsmY, a small regulatory RNA, is required in concert with RsmZ for GacA-dependent expression of biocontrol traits in Pseudomonas fluorescens CHA0". Molecular Microbiology. 50 (4): 1361–1379. doi:10.1046/j.1365-2958.2003.03774.x. PMID 14622422.
  2. ^ Rasis M, Segal G (May 2009). "The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors". Molecular Microbiology. 72 (4): 995–1010. doi:10.1111/j.1365-2958.2009.06705.x. PMID 19400807. S2CID 37262658.

Further reading

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