RsmY RNA family

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RsmY RNA family
RF00195.jpg
Identifiers
Symbol RsmY
Rfam RF00195
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO 0000655

The rsmY RNA family is a set of related non-coding RNA genes, that like RsmZ, is regulated by the GacS/GacA signal transduction system in the plant-beneficial soil bacterium and biocontrol model organism Pseudomonas fluorescens CHA0. GacA/GacS target genes are translationally repressed by the small RNA binding protein RsmA. RsmY and RsmZ RNAs bind RsmA to relieve this repression and so enhance secondary metabolism and biocontrol traits.[1]

Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins LetA and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor.[2]

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References[edit]

  1. ^ Valverde, C; Heeb S; Keel C; Haas D (2003). "RsmY, a small regulatory RNA, is required in concert with RsmZ for GacA-dependent expression of biocontrol traits in Pseudomonas fluorescens CHA0". Mol Microbiol. 50 (4): 1361–1379. doi:10.1046/j.1365-2958.2003.03774.x. PMID 14622422. 
  2. ^ Rasis M, Segal G (May 2009). "The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors". Mol. Microbiol. 72 (4): 995–1010. doi:10.1111/j.1365-2958.2009.06705.x. PMID 19400807. 

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