Rubella virus 3' cis-acting element

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Rubella virus 3' cis-acting element
Predicted secondary structure and sequence conservation of Rubella_3
Symbol Rubella_3
Alt. Symbols Rubella_cis_act
Rfam RF00194
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

The Rubella virus 3' cis-acting element RNA family represents a cis-acting element found at the 3' UTR in the rubella virus. This family contains three conserved step loop structures.[1] Calreticulin (CAL), which is known to bind calcium in most eukaryotic cells, is able to specifically bind to the first stem loop of this RNA.[1] CAL binding is thought to be related to viral pathogenesis and in particular arthritis which occurs frequently in rubella infections in adults and is independent of viral viability. All stem loop structures are thought to be important for efficient viral replication and deletion of stem loop three is known to be lethal.[1]

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  1. ^ a b c Chen, MH; Frey TK (1999). "Mutagenic analysis of the 3' cis-acting elements of the rubella virus genome". J Virol. 73 (4): 3386–3403. PMC 104103Freely accessible. PMID 10074193. 

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