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In 1898, Otto Ruff published his work on the transformation of D-Glucose to D-Arabinose later called the Ruff degradation.
In this reaction, D-Glucose is converted to D-Arabinose . In this reaction, the terminal aldehyde group is converted to a carboxylic acid group, using selective oxidation of the aldehyde using Bromine water and then converted to gluconate ion. Next, Fe(OAc)3 with 30% of H2O2 is added.
Thus COO- ion will form CO2 and a stereo selective compound will form. And below -CH2OH will convert to -CHO group, thus forming D-Arabinose.
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Ruff degradation shortens an aldose chain by removing one carbon