Run-in period

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Run-in period is a period between the recruitment and randomization phases of a clinical trial,[1][2] when all participants receive the same treatment, which may be active treatment, a placebo or no treatment at all. The clinical data from this stage of a trial are only occasionally of value but can serve a valuable role in screening out ineligible or non-compliant participants, in ensuring that participants are in a stable condition, and in providing baseline observations.[3] A run-in period is sometimes called a washout period if treatments that participants were using before entering the clinical trial are discontinued.

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References[edit]

  1. ^ Laursen, David Ruben Teindl; Paludan-Müller, Asger Sand; Hróbjartsson, Asbjørn (2019). "Randomized clinical trials with run-in periods: frequency, characteristics and reporting". Clinical epidemiology. Informa UK Limited. 11: 169–184. doi:10.2147/clep.s188752. ISSN 1179-1349. PMC 6377048. PMID 30809104.
  2. ^ "run-in period". Stedman's Medical Dictionary. Lippincott Williams & Wilkins. 2006. Archived from the original on 2016-03-04 – via MediLexicon.
  3. ^ Bapat, Manasi (September 13, 2021). "Run-in periods in clinical trials: What can we ACHIEVE?". NephJC.