Russian Mission Airport covers an area of 143 acres (58 ha) at an elevation of 51 feet (16 m) above mean sea level. It has one runway designated 17/35 with a 3,600 by 100 ft (1,097 x 30 m) gravel surface. It also has a seaplane landing area designated 18W/36W which covers an area of the Yukon River measuring 3,000 by 500 ft (914 x 152 m).
On Wednesday, August 31, 2016, a collision occurred near Russian Mission Airport involving a Ravn Connect Cessna Caravan 208B EX aircraft that had been leased from Hageland Aviation Services and a Renfro's Alaskan Adventures Piper PA-18 Super Cub, killing the three people on board the Cessna Caravan 208B and the two on board the Piper aircraft. The Ravn Connect flight was a commercial one from Russian Mission Airport to Marshall Don Hunter Sr. Airport in Marshall, Alaska, while the Renfro's Alaskan Adventures aircraft was on a charter flight from Bethel Airport to a hunting location.