"S.E.X." debuted on the Billboard Hot 100 chart at number 99 and slipped off just to re-enter the following week again at number 99. It eventually peaked at number 37, making it Lyfe's most successful single. "S.E.X." was a top-five hit on the BillboardHot R&B/Hip-Hop Songs chart and received strong airplay on BET and some airplay on radio and MTV.