The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A11 is localized in the cytoplasm of resting human keratinocytes in vitro.
S100A11, along with all 13 members of the S100 family, are located as a cluster on chromosome 1q21. The protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis.
Suppression of S100A11 by small interfering RNA caused cells to apoptose, and overexpression of S100A11 has been found to inhibit apoptosis in tumor cells.
IL-8 and TNF-alpha induce S100A11 expression and release in chondrocytes in culture and exogenous S100A11 causes chondrocyte hypertrophy.
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