S100A12

From Wikipedia, the free encyclopedia
Jump to: navigation, search
S100A12
Protein S100A12 PDB 1e8a.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, S100 calcium binding protein A12
External IDs HomoloGene: 48361 GeneCards: S100A12
RNA expression pattern
PBB GE S100A12 205863 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005621

n/a

RefSeq (protein)

NP_005612

n/a

Location (UCSC) Chr 1: 153.37 – 153.38 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene.[2][3] It is also known as calgranulin C.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (Mar 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590. 
  3. ^ a b "Entrez Gene: S100A12 S100 calcium binding protein A12". 

Further reading[edit]