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Protein S100A6 PDB 1a03.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesS100A6, 2A9, 5B10, CABP, CACY, PRA, S100 calcium binding protein A6, S10A6
External IDsOMIM: 114110 MGI: 1339467 HomoloGene: 7925 GeneCards: S100A6
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for S100A6
Genomic location for S100A6
Band1q21.3Start153,534,599 bp[1]
End153,536,244 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 153.53 – 153.54 MbChr 3: 90.61 – 90.62 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.[5]


The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.[5]


S100A6 has been shown to interact with S100B[6][7] and SUGT1.[8]


S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197956 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001025 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: S100A6 S100 calcium binding protein A6".
  6. ^ Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (November 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
  7. ^ Yang Q, O'Hanlon D, Heizmann CW, Marks A (February 1999). "Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma". Exp. Cell Res. 246 (2): 501–9. doi:10.1006/excr.1998.4314. PMID 9925766.
  8. ^ Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
  9. ^ Sofiadis A, Dinets A, Orre LM, Branca RM, Juhlin CC, Foukakis T, Wallin G, Höög A, Hulchiy M, Zedenius J, Larsson C, Lehtiö J (October 2010). "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma". Thyroid. 20 (10): 1067–76. doi:10.1089/thy.2009.0400. PMID 20629554.

Further reading[edit]