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S18, S-18 or S.18 may refer to:
- In military
- Letov Š-18, a 1925 Czechoslovak single-engined two-seat biplane trainer
- Saab 18, a twin engine bomber and reconnaissance aircraft.
- USS S-18 (SS-123), a 1920 S-class submarine of the United States Navy
- a variant of 85 mm air defense gun M1939 (52-K)
- In transportation
- S18 (ZVV), a 1,000 mm (3 ft 3⅜ in) gauge narrow-gauge light railway in Zürich
- County Route S18 (California), a road in California
- Rans S-18 Stinger II, ultralight aircraft
- Thorp S-18 amateur-built aircraft design
- In science and academia
- S18: Handle and open container with care, a safety phrase in chemistry
S18 may refer to:
- a cyclic allotrope of sulfur
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