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Sphingosine-1-phosphate receptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols S1PR2 ; AGR16; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2
External IDs OMIM605111 MGI99569 HomoloGene3118 IUPHAR: 276 ChEMBL: 2955 GeneCards: S1PR2 Gene
RNA expression pattern
PBB GE EDG5 208537 at tn.png
More reference expression data
Species Human Mouse
Entrez 9294 14739
Ensembl ENSG00000267534 ENSMUSG00000043895
UniProt O95136 P52592
RefSeq (mRNA) NM_004230 NM_010333
RefSeq (protein) NP_004221 NP_034463
Location (UCSC) Chr 19:
10.22 – 10.23 Mb
Chr 9:
20.97 – 20.98 Mb
PubMed search [1] [2]

Sphingosine-1-phosphate receptor 2 also known as S1PR2 or S1P2 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[1]


This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.