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Aliases S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs MGI: 1339365 HomoloGene: 3829 GeneCards: S1PR3
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for S1PR3
Genomic location for S1PR3
Band 9q22.1 Start 88,991,447 bp[1]
End 89,005,010 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 88.99 – 89.01 Mb Chr 9: 51.41 – 51.42 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P3.[5]


This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.[5]

See also[edit]


Further reading[edit]

  • Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 16–24. PMID 10818438. doi:10.1111/j.1749-6632.2000.tb06534.x. 
  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441. doi:10.1111/j.1749-6632.2000.tb06537.x. 
  • Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing.". Ann. N. Y. Acad. Sci. 905: 142–58. PMID 10818450. doi:10.1111/j.1749-6632.2000.tb06546.x. 
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348. 
  • Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils.". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355. 
  • Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.". Biochem. Biophys. Res. Commun. 227 (2): 608–14. PMID 8878560. doi:10.1006/bbrc.1996.1553. 
  • An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. PMID 9409733. doi:10.1016/S0014-5793(97)01301-X. 
  • Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.". J. Biol. Chem. 274 (8): 4626–32. PMID 9988698. doi:10.1074/jbc.274.8.4626. 
  • Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway.". Blood. 93 (9): 2984–90. PMID 10216094. 
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. PMID 10383399. doi:10.1074/jbc.274.27.18997. 
  • Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065. doi:10.1074/jbc.274.39.27351. 
  • Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.". Cancer Res. 59 (20): 5370–5. PMID 10537322. 
  • Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell. 99 (3): 301–12. PMID 10555146. doi:10.1016/S0092-8674(00)81661-X. 
  • An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.". J. Biol. Chem. 275 (1): 288–96. PMID 10617617. doi:10.1074/jbc.275.1.288. 
  • Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor.". Arch. Biochem. Biophys. 375 (1): 69–77. PMID 10683250. doi:10.1006/abbi.1999.1589. 
  • Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. PMID 10712250. 
  • Kimura T, Watanabe T, Sato K, et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3.". Biochem. J. 348 (1): 71–6. PMC 1221037Freely accessible. PMID 10794715. doi:10.1042/0264-6021:3480071. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.