S22 may refer to :
- S22: Do not breathe dust, a safety phrase in chemistry
- Scattering parameters, Electrical Engineering - Matrix Element S22 - reflection coefficient
- Brazilian submarine Riachuelo (S22), a 1975 Oberon-class submarine in the Brazilian Navy
- British NVC community S22, a swamps and tall-herb fens community in the British National Vegetation Classification system
- Chery S22, a Chinese Chery Automobile model
- Chilean submarine O'Brien (S22), a 1972 Oberon-class submarine in the Chilean Navy
- County Route S22 (California)
- Expressway S22 (Poland)
- HMS Resolution (S22), a 1963 British Royal Navy's Resolution-class ballistic missile submarine
- Sikorsky Ilya Muromets
- USS S-22 (SS-127), a 1920 S-class submarine of the United States Navy
- a shortening or designation for
- a Zürich S-Bahn line
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