S46, S-46 or S.46 may refer to:
- S46 (Berlin), a public transportation route in Germany
- S46: If swallowed, seek medical advice immediately and show this container or label, a safety phrase in chemistry
- S46 (New York City bus), a bus serving Staten Island
- Blériot-SPAD S.46, a French commercial airliner which flew during the 1920s
- HMS Churchill (S46), a United Kingdom Royal Navy nuclear-powered submarine which was decommissioned in 1991
- SABCA S-46, a Belgian aircraft
- Semangat 46, a defunct political party in Malaysia
- USS S-46 (SS-157), a 1923 United States Navy submarine which saw service during World War II
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