SART1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Squamous cell carcinoma antigen recognized by T cells
Identifiers
Symbols SART1 ; Ara1; HOMS1; SART1259; SNRNP110; Snu66
External IDs OMIM605941 MGI1309453 HomoloGene133770 GeneCards: SART1 Gene
RNA expression pattern
PBB GE SART1 200052 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9092 20227
Ensembl ENSG00000175467 ENSMUSG00000039148
UniProt O43290 Q9Z315
RefSeq (mRNA) NM_005146 NM_016882
RefSeq (protein) NP_005137 NP_058578
Location (UCSC) Chr 11:
65.73 – 65.75 Mb
Chr 19:
5.38 – 5.39 Mb
PubMed search [1] [2]

U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene.[1][2] This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.[2]

References[edit]

  1. ^ Shichijo S, Nakao M, Imai Y, Takasu H, Kawamoto M, Niiya F, Yang D, Toh Y, Yamana H, Itoh K (Mar 1998). "A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes". J Exp Med 187 (3): 277–88. doi:10.1084/jem.187.3.277. PMC 2212124. PMID 9449708. 
  2. ^ a b "Entrez Gene: SART1 squamous cell carcinoma antigen recognized by T cells". 

Further reading[edit]