SB-357134

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SB-357134
SB357134.png
Identifiers
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
Formula C17H18Br2FN3O3S
Molar mass 523.214 g/mol
3D model (JSmol)
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SB-357134 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist.[1] SB-357134 and other 5-HT6 antagonists show nootropic effects in animal studies,[2][3][4] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.

References[edit]

  1. ^ Bromidge, SM; Clarke, SE; Gager, T; Griffith, K; Jeffrey, P; Jennings, AJ; Joiner, GF; King, FD; et al. (2001). "Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)". Bioorganic & Medicinal Chemistry Letters. 11 (1): 55–8. doi:10.1016/S0960-894X(00)00597-7. PMID 11140733. 
  2. ^ Rogers, DC; Hagan, JJ (2001). "5-HT6 receptor antagonists enhance retention of a water maze task in the rat". Psychopharmacology. 158 (2): 114–9. doi:10.1007/s002130100840. PMID 11702084. 
  3. ^ Stean, TO; Hirst, WD; Thomas, DR; Price, GW; Rogers, D; Riley, G; Bromidge, SM; Serafinowska, HT; et al. (2002). "Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist". Pharmacology Biochemistry and Behavior. 71 (4): 645–54. doi:10.1016/S0091-3057(01)00742-0. PMID 11888556. 
  4. ^ Perez-García, G; Meneses, A (2005). "Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task". Pharmacology Biochemistry and Behavior. 81 (3): 673–82. doi:10.1016/j.pbb.2005.05.005. PMID 15964617.