SCIN

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SCIN
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SCIN, scinderin
External IDs MGI: 1306794 HomoloGene: 36296 GeneCards: SCIN
RNA expression pattern
PBB GE SCIN 222272 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001112706
NM_033128

NM_001146196
NM_009132

RefSeq (protein)

NP_001106177
NP_149119

NP_001139668.1
NP_033158.2
NP_001139668
NP_033158

Location (UCSC) Chr 7: 12.57 – 12.66 Mb Chr 12: 40.06 – 40.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Scinderin (also known as adseverin) is a protein that in humans is encoded by the SCIN gene.[3] Scinderin is an actin severing protein belonging to the gelsolin superfamily.[4] It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, Calcium channels open allowing calcim ions to enter de secretory cell. Increase in intracellualr calcium activates scinderin with the consecuent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: SCIN scinderin". 
  4. ^ Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. 

Further reading[edit]