SCN3A

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SCN3A
Protein SCN3A PDB 1byy.png
Identifiers
Aliases SCN3A, NAC3, Nav1.3, sodium voltage-gated channel alpha subunit 3
External IDs MGI: 98249 HomoloGene: 56005 GeneCards: 6328
RNA expression pattern
PBB GE SCN3A 210432 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081676
NM_001081677
NM_006922

NM_018732

RefSeq (protein)

NP_001075145.1
NP_001075146.1
NP_008853.3

n/a

Location (UCSC) Chr 2: 165.09 – 165.2 Mb Chr 2: 65.46 – 65.57 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sodium channel, voltage-gated, type III, alpha subunit (SCN3A) is a protein that in humans is encoded by the Nav1.3 gene.[1]

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

SCN3A is the only sodium channel transcript which is changed after nerve injury.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.