SCN7A

SCN7A
Identifiers
Aliases	SCN7A, NaG, Nav2.1, Nav2.2, SCN6A, sodium voltage-gated channel alpha subunit 7
External IDs	OMIM: 182392; MGI: 102965; HomoloGene: 55706; GeneCards: SCN7A; OMA:SCN7A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.3 Start 166,403,573 bp End 166,611,482 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 C1.3|2 39.21 cM Start 66,503,769 bp End 66,615,258 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion sural nerve right lung spinal ganglia lower lobe of lung seminal vesicula right ventricle left ovary visceral pleura muscle layer of sigmoid colon Top expressed in left lung lobe carotid body median eminence lumbar spinal ganglion right lung right lung lobe white adipose tissue trigeminal ganglion arcuate nucleus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity sodium channel activity voltage-gated ion channel activity voltage-gated sodium channel activity Cellular component voltage-gated sodium channel complex integral component of membrane plasma membrane membrane axon glial cell projection Biological process regulation of ion transmembrane transport muscle contraction membrane depolarization during action potential ion transport sodium ion transmembrane transport transmembrane transport neuronal action potential sodium ion transport ion transmembrane transport response to bacterium sodium ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6332 20272 Ensembl ENSG00000136546 ENSMUSG00000034810 UniProt Q01118 n/a RefSeq (mRNA) NM_002976 NM_009135 RefSeq (protein) NP_002967 n/a Location (UCSC) Chr 2: 166.4 – 166.61 Mb Chr 2: 66.5 – 66.62 Mb PubMed search
Wikidata
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Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome specifically located at 2q21-23 chromosome site. This is one of 10 Sodium channel types, and is expressed in the heart, the uterus and in glial cells. Its sequence identity is 48, and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin).

See also

• Sodium channel

Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Na_x (also known as NaG, Na_v2.1, etc.) It belongs to a family of Sodium Channel known as Voltage-Gated, but is not activated by changes in the membrane's voltage, as happen usually in the members of this family (Na_v1.1 to Na_v1.9); it activates by changes in the extracellular concentration of sodium [~150 mM].

External links

• SCN7A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.