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Sodium channel, non voltage gated 1 gamma subunit
Symbols SCNN1G ; BESC3; ENaCg; ENaCgamma; PHA1; SCNEG
External IDs OMIM600761 MGI104695 HomoloGene20280 IUPHAR: 741 ChEMBL: 1628484 GeneCards: SCNN1G Gene
Species Human Mouse
Entrez 6340 20278
Ensembl ENSG00000166828 ENSMUSG00000000216
UniProt P51170 Q9WU39
RefSeq (mRNA) NM_001039 NM_011326
RefSeq (protein) NP_001030 NP_035456
Location (UCSC) Chr 16:
23.18 – 23.22 Mb
Chr 7:
121.73 – 121.77 Mb
PubMed search [1] [2]

Amiloride-sensitive sodium channel subunit gamma is a protein that in humans is encoded by the SCNN1G gene.[1][2]


SCNN1G has been shown to interact with:

See also[edit]


  1. ^ Voilley N, Bassilana F, Mignon C, Merscher S, Mattéi MG, Carle GF et al. (January 1996). "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel". Genomics 28 (3): 560–5. doi:10.1006/geno.1995.1188. PMID 7490094. 
  2. ^ "Entrez Gene: SCNN1G sodium channel, nonvoltage-gated 1, gamma". 
  3. ^ Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. 345 Pt 3: 503–9. doi:10.1042/0264-6021:3450503. PMC 1220784. PMID 10642508. 
  4. ^ McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. PMID 12167593. 
  5. ^ Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092. 
  6. ^ Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER et al. (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. PMID 14996668. 
  7. ^ Boulkroun S, Ruffieux-Daidié D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D et al. (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. PMID 18632802. 
  8. ^ Raikwar NS, Thomas CP (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. PMC 2424110. PMID 18322022. 

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