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Sodium channel, non voltage gated 1 gamma subunit
Symbols SCNN1G ; BESC3; ENaCg; ENaCgamma; PHA1; SCNEG
External IDs OMIM600761 MGI104695 HomoloGene20280 IUPHAR: 741 ChEMBL: 1628484 GeneCards: SCNN1G Gene
Species Human Mouse
Entrez 6340 20278
Ensembl ENSG00000166828 ENSMUSG00000000216
UniProt P51170 Q9WU39
RefSeq (mRNA) NM_001039 NM_011326
RefSeq (protein) NP_001030 NP_035456
Location (UCSC) Chr 16:
23.18 – 23.22 Mb
Chr 7:
121.73 – 121.77 Mb
PubMed search [1] [2]

Amiloride-sensitive sodium channel subunit gamma is a protein that in humans is encoded by the SCNN1G gene.[1][2]


SCNN1G has been shown to interact with:

See also[edit]


  1. ^ Voilley N, Bassilana F, Mignon C, Merscher S, Mattéi MG, Carle GF, Lazdunski M, Barbry P (January 1996). "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel". Genomics 28 (3): 560–5. doi:10.1006/geno.1995.1188. PMID 7490094. 
  2. ^ "Entrez Gene: SCNN1G sodium channel, nonvoltage-gated 1, gamma". 
  3. ^ Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. 345 Pt 3: 503–9. doi:10.1042/0264-6021:3450503. PMC 1220784. PMID 10642508. 
  4. ^ McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. PMID 12167593. 
  5. ^ Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092. 
  6. ^ Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER, Benos DJ (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. PMID 14996668. 
  7. ^ Boulkroun S, Ruffieux-Daidié D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. PMID 18632802. 
  8. ^ Raikwar NS, Thomas CP (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. PMC 2424110. PMID 18322022. 

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