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AliasesSSPO, SCO-spondin
External IDsMGI: 2674311 HomoloGene: 45453 GeneCards: SSPO
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SSPO
Genomic location for SSPO
Band7q36.1Start149,776,042 bp[1]
End149,833,979 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 149.78 – 149.83 MbChr 6: 48.45 – 48.5 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

SCO-spondin is a protein that in humans is encoded by the SSPO gene.[5][6][7] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197558 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029797 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5): 1053–61. PMID 8743952. 
  6. ^ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. 
  7. ^ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)". 
  8. ^ Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. 

Further reading[edit]