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Symbols SSPO ; SCO-spondin
External IDs MGI2674311 HomoloGene45453 GeneCards: SSPO Gene
Species Human Mouse
Entrez 23145 243369
Ensembl ENSG00000197558 ENSMUSG00000029797
UniProt A2VEC9 Q8CG65
RefSeq (mRNA) NM_198455 NM_173428
RefSeq (protein) NP_940857 NP_775604
Location (UCSC) Chr 7:
149.78 – 149.83 Mb
Chr 6:
48.45 – 48.5 Mb
PubMed search [1] [2]

SCO-spondin is a protein that in humans is encoded by the SSPO gene.[1][2][3] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[4]


  1. ^ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (Dec 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". J Cell Sci. 109. ( Pt 5): 1053–61. PMID 8743952. 
  2. ^ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (Nov 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. 
  3. ^ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)". 
  4. ^ Gobron, S.; Creveaux, I.; Meiniel, R.; Didier, R.; Dastugue, B.; Meiniel, A. (1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience 88 (2): 655–664. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. 

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