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SDB-006 structure.png
Legal status
Legal status
CAS Number
PubChem CID
Chemical and physical data
Formula C21H24N2O
Molar mass 320.43 g/mol
3D model (JSmol)

SDB-006 is a drug that acts as a potent agonist for the cannabinoid receptors, with an EC50 of 19 nM for human CB2 receptors, and 134 nM for human CB1 receptors.[1][2] It was discovered during research into the related compound SDB-001 which had been sold illicitly as "2NE1".[3] SDB-006 metabolism has been described in literature.[4]

See also[edit]


  1. ^ Banister, S. D.; Stuart, J.; Kevin, R. C.; Edington, A.; Longworth, M.; Wilkinson, S. M.; Beinat, C.; Buchanan, A. S.; Hibbs, D. E.; Glass, M.; Connor, M.; McGregor, I. S.; Kassiou, M. (2015). "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135". ACS Chemical Neuroscience. 6: 150508124201002. doi:10.1021/acschemneuro.5b00107. PMID 25921407. 
  2. ^ Banister, Samuel D.; Olson, Alexander; Winchester, Matthew; Stuart, Jordyn; Edington, Amelia R.; Kevin, Richard C.; Longworth, Mitchell; Herrera, Marco; Connor, Mark; McGregor, Iain S.; Gerona, Roy R.; Kassiou, Michael (2018). "The chemistry and pharmacology of synthetic cannabinoid SDB-006 and its regioisomeric fluorinated and methoxylated analogues". Drug Testing and Analysis. doi:10.1002/dta.2362. PMID 29350472. 
  3. ^ Banister, S. D.; Wilkinson, S. M.; Longworth, M.; Stuart, J.; Apetz, N.; English, K.; Brooker, L.; Goebel, C.; Hibbs, D. E.; Glass, M.; Connor, M.; McGregor, I. S.; Kassiou, M. (2013). "The synthesis and pharmacological evaluation of adamantane-derived indoles: Novel cannabimimetic drugs of abuse". ACS Chemical Neuroscience. 4 (7): 130403084729007. doi:10.1021/cn400035r. PMC 3715837Freely accessible. PMID 23551277. 
  4. ^ Xingxing Diao; Jeremy Carlier; Karl B. Scheidweiler; Marilyn A. Huestis (July 2017). "In vitro metabolism of new synthetic cannabinoid SDB-006 in human hepatocytes by high-resolution mass spectrometry". Forensic Toxicology. 35 (2): 252–262. doi:10.1007/s11419-016-0350-9.