SDK2

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SDK2
Protein SDK2 PDB 1wf5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SDK2
External IDs MGI: 2443847 HomoloGene: 10406 GeneCards: SDK2
Genetically Related Diseases
panic disorder[1]
RNA expression pattern
PBB GE SDK2 220628 s at fs.png

PBB GE SDK2 gnf1h03181 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144952
NM_019064

NM_172800

RefSeq (protein)

NP_001138424

NP_766388.2
NP_766388

Location (UCSC) Chr 17: 73.33 – 73.64 Mb Chr 11: 113.78 – 114.07 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse
For the Japanese game, see Super Donkey Kong 2

Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.[4][5][6]

The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.[6]

References[edit]

  1. ^ "Diseases that are genetically associated with SDK2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Yamagata M, Weiner JA, Sanes JR (Sep 2002). "Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina". Cell. 110 (5): 649–60. doi:10.1016/S0092-8674(02)00910-8. PMID 12230981. 
  5. ^ Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (Jun 2004). "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J Am Soc Nephrol. 15 (7): 1721–30. doi:10.1097/01.ASN.0000128975.28958.C2. PMID 15213259. 
  6. ^ a b "Entrez Gene: SDK2 sidekick homolog 2 (chicken)". 

Further reading[edit]