SDPR

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SDPR
Identifiers
Aliases SDPR, CAVIN2, PS-p68, SDR, cavin-2, serum deprivation response
External IDs MGI: 99513 HomoloGene: 3422 GeneCards: SDPR
RNA expression pattern
PBB GE SDPR 218711 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004657

NM_138741

RefSeq (protein)

NP_004648

NP_620080.1
NP_620080

Location (UCSC) Chr 2: 191.83 – 191.85 Mb Chr 1: 51.29 – 51.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serum deprivation-response protein is a protein that in humans is encoded by the SDPR gene.[3][4][5]

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.[5]

SDPR is shown to act as a metastasis suppressor by xenograft studies utilizing breast cancer cell lines.[6] SDPR may elicit its metastasis suppressor function by directly interacting with ERK and limiting its pro-survival role.[6] Moreover, it is suggested that SDPR is silenced during breast cancer progression by promoter DNA methylation.[6] Metastasis suppressor role of SDPR may go beyond breast cancer since tumor samples from bladder, colorectal, lung, pancreatic, and ovarian cancers as well as sarcomas also exhibited loss of SDPR expression.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gustincich S, Vatta P, Goruppi S, Wolf M, Saccone S, Della Valle G, Baggiolini M, Schneider C (Jun 1999). "The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein". Genomics. 57 (1): 120–9. doi:10.1006/geno.1998.5733. PMID 10191091. 
  4. ^ Gustincich S, Schneider C (Dec 1993). "Serum deprivation response gene is induced by serum starvation but not by contact inhibition". Cell Growth Differ. 4 (9): 753–60. PMID 8241023. 
  5. ^ a b "Entrez Gene: SDPR serum deprivation response (phosphatidylserine binding protein)". 
  6. ^ a b c d Sait Ozturk; Panagiotis Papageorgis; Chen Khuan Wong; Arthur W. Lambert; Hamid M. Abdolmaleky; Arunthathi Thiagalingam; Herbert T. Cohen & Sam Thiagalingam (Jan 2016). "SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis". PNAS. 113: 638–643. doi:10.1073/pnas.1514663113. PMC 4725521Freely accessible. PMID 26739564. 

Further reading[edit]