SDPR is shown to act as a metastasis suppressor by xenograft studies utilizing breast cancer cell lines. SDPR may elicit its metastasis suppressor function by directly interacting with ERK and limiting its pro-survival role. Moreover, it is suggested that SDPR is silenced during breast cancer progression by promoterDNA methylation. Metastasis suppressor role of SDPR may go beyond breast cancer since tumor samples from bladder, colorectal, lung, pancreatic, and ovarian cancers as well as sarcomas also exhibited loss of SDPR expression.
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