SEC61G

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SEC61G
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases SEC61G, SSS1, Sec61 translocon gamma subunit
External IDs HomoloGene: 40767 GeneCards: SEC61G
RNA expression pattern
PBB GE SEC61G 203484 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014302
NM_001012456

n/a

RefSeq (protein)

NP_001012474
NP_055117

n/a

Location (UCSC) Chr 7: 54.75 – 54.76 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.[2][3][4]

Function[edit]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851. 
  3. ^ Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. PMID 10212142. 
  4. ^ a b "Entrez Gene: SEC61G Sec61 gamma subunit". 

Further reading[edit]