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Aliases SEMA3F, SEMA-IV, SEMA4, SEMAK, semaphorin 3F
External IDs MGI: 1096347 HomoloGene: 20885 GeneCards: SEMA3F
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SEMA3F
Genomic location for SEMA3F
Band 3p21.31 Start 50,155,045 bp[1]
End 50,189,075 bp[1]
RNA expression pattern
PBB GE SEMA3F 206832 s at fs.png

PBB GE SEMA3F 209730 at fs.png

PBB GE SEMA3F 35666 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 50.16 – 50.19 Mb Chr 9: 107.68 – 107.71 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Semaphorin-3F is a protein that in humans is encoded by the SEMA3F gene.[5][6][7]

The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993). Sequence comparisons have grouped the secreted semaphorins into 3 general classes (classes 2, 3 and V), all of which also have an immunoglobulin domain. The semaphorin 3 family, consisting of human semaphorins 3A-G (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins 3A-G, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000001617 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034684 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Xiang RH, Hensel CH, Garcia DK, Carlson HC, Kok K, Daly MC, Kerbacher K, van den Berg A, Veldhuis P, Buys CH, Naylor SL (Sep 1996). "Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer". Genomics. 32 (1): 39–48. doi:10.1006/geno.1996.0074. PMID 8786119. 
  6. ^ Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, Swanton M, Waggoner B, Fishel R, Franklin W, Gemmill R, Drabkin H (Jul 1996). "Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin". Oncogene. 12 (6): 1289–97. PMID 8649831. 
  7. ^ a b "Entrez Gene: SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F". 

Further reading[edit]