SEMA4A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SEMA4A
Identifiers
Aliases SEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
External IDs MGI: 107560 HomoloGene: 8425 GeneCards: SEMA4A
RNA expression pattern
PBB GE SEMA4A 219259 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001193300
NM_001193301
NM_001193302
NM_022367

NM_001163489
NM_001163490
NM_001163491
NM_013658

RefSeq (protein)

NP_001180229
NP_001180230
NP_001180231
NP_071762

Location (UCSC) Chr 1: 156.15 – 156.18 Mb Chr 3: 88.44 – 88.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.[3][4]

Function[edit]

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM][4]

Clinical significance[edit]

A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Püschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561. 
  4. ^ a b "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A". 
  5. ^ Schulz E, Klampfl P, Holzapfel S, Janecke AR, Ulz P, Renner W, Kashofer K, Nojima S, Leitner A, Zebisch A, Wölfler A, Hofer S, Gerger A, Lax S, Beham-Schmid C, Steinke V, Heitzer E, Geigl JB, Windpassinger C, Hoefler G, Speicher MR, Richard Boland C, Kumanogoh A, Sill H (Oct 2014). "Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.". Nature Communications. 5: 5191. doi:10.1038/ncomms6191. PMC 4214414Freely accessible. PMID 25307848. 

Further reading[edit]