SEMA5A

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SEMA5A
Identifiers
AliasesSEMA5A, SEMAF, semF, semaphorin 5A
External IDsMGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SEMA5A
Genomic location for SEMA5A
Band5p15.31Start9,035,026 bp[1]
End9,546,075 bp[1]
RNA expression pattern
PBB GE SEMA5A 205405 at fs.png

PBB GE SEMA5A 213169 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003966

NM_009154

RefSeq (protein)

NP_003957

NP_033180

Location (UCSC)Chr 5: 9.04 – 9.55 MbChr 15: 32.24 – 32.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[5][6][7]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][7]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112902 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022231 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
  6. ^ Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
  7. ^ a b "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading[edit]