SEMA5A

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SEMA5A
Identifiers
Aliases SEMA5A, SEMAF, semF, semaphorin 5A
External IDs MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Genetically Related Diseases
obesity, Parkinson's disease[1]
RNA expression pattern
PBB GE SEMA5A 205405 at fs.png

PBB GE SEMA5A 213169 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003966

NM_009154

RefSeq (protein)

NP_003957

n/a

Location (UCSC) Chr 5: 9.04 – 9.55 Mb Chr 15: 32.24 – 32.7 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[4][5][6]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][6]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

References[edit]

  1. ^ "Diseases that are genetically associated with SEMA5A view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451. 
  5. ^ Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278. 
  6. ^ a b "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A". 

Further reading[edit]