SEMA7A

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SEMA7A
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SEMA7A, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group)
External IDs MGI: 1306826 HomoloGene: 2678 GeneCards: 8482
RNA expression pattern
PBB GE SEMA7A 210083 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003612
NM_001146029
NM_001146030

NM_011352

RefSeq (protein)

NP_001139501.1
NP_001139502.1
NP_003603.1

NP_035482.1

Location (UCSC) Chr 15: 74.41 – 74.43 Mb Chr 9: 57.94 – 57.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.[3]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM][3]

Genetics[edit]

This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

Molecular biology[edit]

This protein forms dimers.

Notes[edit]

This protein acts as a receptor for the malaria parasite Plasmodium falciparum.

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.