From Wikipedia, the free encyclopedia
Jump to: navigation, search
Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SEMA7A ; CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL
External IDs OMIM607961 MGI1306826 HomoloGene2678 GeneCards: SEMA7A Gene
RNA expression pattern
PBB GE SEMA7A 210083 at tn.png
More reference expression data
Species Human Mouse
Entrez 8482 20361
Ensembl ENSG00000138623 ENSMUSG00000038264
UniProt O75326 Q9QUR8
RefSeq (mRNA) NM_001146029 NM_011352
RefSeq (protein) NP_001139501 NP_035482
Location (UCSC) Chr 15:
74.41 – 74.43 Mb
Chr 9:
57.94 – 57.96 Mb
PubMed search [1] [2]

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.[1]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM][1]


This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

Molecular biology[edit]

This protein forms dimers.


This protein acts as a receptor for the malaria parasite Plasmodium falciparum.

See also[edit]


Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.