SEPX1

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MSRB1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1
External IDs MGI: 1351642 HomoloGene: 8455 GeneCards: MSRB1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016332

NM_013759
NM_001346668

RefSeq (protein)

NP_057416

NP_038787.1
NP_001333597
NP_038787

Location (UCSC) Chr 16: 1.94 – 1.94 Mb Chr 17: 24.74 – 24.74 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.[3][4]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem. 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886. 
  4. ^ a b "Entrez Gene: SEPX1 selenoprotein X, 1". 

Further reading[edit]