SERPINB1

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SERPINB1
1HLE.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SERPINB1, EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2, HEL-S-27, serpin family B member 1
External IDs MGI: 1913472 HomoloGene: 133768 GeneCards: SERPINB1
RNA expression pattern
PBB GE SERPINB1 213572 s at fs.png

PBB GE SERPINB1 212268 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030666

NM_025429

RefSeq (protein)

NP_109591

NP_079705.2
NP_079705

Location (UCSC) Chr 6: 2.83 – 2.84 Mb Chr 13: 32.84 – 32.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[3][4][5]

MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.[5]

Function[edit]

SerpinB1 is a cytoplasmic serine protease inhibitor of polymorphonuclear neutrophils. Among other serine proteases, it specifically inhibits neutrophil elastase, PR3 and cathepsin G, all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.[6][7][8]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. doi:10.1073/pnas.89.12.5635. PMC 49347Freely accessible. PMID 1376927. 
  4. ^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1". 
  5. ^ a b Benarafa C, Remold-O'Donnell E (August 2005). "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. doi:10.1073/pnas.0502934102. PMC 1183561Freely accessible. PMID 16055559. 
  6. ^ Gong D, Farley K, White M, Hartshorn KL, Benarafa C, Remold-O'Donnell E (August 2011). "Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection". J. Infect. Dis. 204 (4): 592–600. doi:10.1093/infdis/jir352. PMC 3144176Freely accessible. PMID 21791661. 
  7. ^ Benarafa C, LeCuyer TE, Baumann M, Stolley JM, Cremona TP, Remold-O'Donnell E (July 2011). "SerpinB1 protects the mature neutrophil reserve in the bone marrow". J. Leukoc. Biol. 90 (1): 21–9. doi:10.1189/jlb.0810461. PMC 3114599Freely accessible. PMID 21248149. 
  8. ^ Benarafa C, Priebe GP, Remold-O'Donnell E (August 2007). "The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection". J. Exp. Med. 204 (8): 1901–9. doi:10.1084/jem.20070494. PMC 2118684Freely accessible. PMID 17664292. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.