SERPINI2

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SERPINI2
Identifiers
Aliases SERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2
External IDs MGI: 1915181 HomoloGene: 21248 GeneCards: SERPINI2
RNA expression pattern
PBB GE SERPINI2 207636 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006217
NM_001012303

NM_026460

RefSeq (protein)

NP_001012303
NP_006208

NP_080736.2
NP_080736

Location (UCSC) Chr 3: 167.44 – 167.48 Mb Chr 3: 75.24 – 75.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (July 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes, Chromosomes & Cancer. 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID 9624529. 
  4. ^ a b "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.026