Protein SET

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Protein SET PDB 2e50.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases SET, 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, SET nuclear proto-oncogene
External IDs MGI: 1860267 HomoloGene: 55707 GeneCards: SET
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SET
Genomic location for SET
Band 9q34.11 Start 128,683,424 bp[1]
End 128,696,400 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 128.68 – 128.7 Mb Chr 9: 30.06 – 30.07 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Protein SET is a protein that in humans is encoded by the SET gene.[5][6][7]


Protein SET has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119335 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054766 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582Freely accessible. PMID 1630450. 
  6. ^ Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647. 
  7. ^ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)". 
  8. ^ a b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245. 
  9. ^ Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744Freely accessible. PMID 11909973. 
  10. ^ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927. 
  11. ^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669Freely accessible. PMID 14612398. 
  12. ^ Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186. 

Further reading[edit]