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SF1 may refer to:
- SF1 (gene), a human gene
- SRF 1, a Swiss television channel formerly known as 'SF 1'
- Star Fox (video game), the first game in the Star Fox series
- Street Fighter (video game), the first game in the Street Fighter series
- Steroidogenic factor 1
- SF-1 SNES TV, a television monitor sold by Sharp Corporation with a built-in Super NES
- Summary File 1, a United States Census report
- a type of helicase, a common protein.
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