SF1 (gene)

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Protein SF1 PDB 1k1g.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1
External IDs HomoloGene: 138518 GeneCards: SF1
RNA expression pattern
PBB GE SF1 208313 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 11: 64.76 – 64.78 Mb n/a
PubMed search [1] n/a
View/Edit Human

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.[2][3][4]

Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.[5]


SF1 (gene) has been shown to interact with Ewing sarcoma breakpoint region 1,[6] U2AF2,[7][8][9] Testis determining factor,[10] and Transcription elongation regulator 1.[11]


  1. ^ "Human PubMed Reference:". 
  2. ^ Toda T, Iida A, Miwa T, Nakamura Y, Imai T (Jul 1994). "Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)". Hum Mol Genet. 3 (3): 465–70. doi:10.1093/hmg/3.3.465. PMID 7912130. 
  3. ^ Kramer A, Quentin M, Mulhauser F (Jun 1998). "Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene". Gene. 211 (1): 29–37. doi:10.1016/S0378-1119(98)00058-4. PMID 9573336. 
  4. ^ "Entrez Gene: SF1 splicing factor 1". 
  5. ^ Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M (May 2008). "Splicing factors SF1 and U2AF associate in extraspliceosomal complexes". Mol. Cell. Biol. 28 (9): 3045–57. doi:10.1128/MCB.02015-07. PMC 2293075Freely accessible. PMID 18285458. 
  6. ^ Zhang D, Paley AJ, Childs G (July 1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi:10.1074/jbc.273.29.18086. PMID 9660765. 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ Berglund JA, Abovich N, Rosbash M (March 1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition". Genes Dev. 12 (6): 858–67. doi:10.1101/gad.12.6.858. PMC 316625Freely accessible. PMID 9512519. 
  9. ^ Abovich N, Rosbash M (May 1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals". Cell. 89 (3): 403–12. doi:10.1016/S0092-8674(00)80221-4. PMID 9150140. 
  10. ^ Kashimada K, Koopman P (December 2010). "Sry: the master switch in mammalian sex determination". Development. 137 (23): 3921–30. doi:10.1242/dev.048983. PMID 21062860. 
  11. ^ Goldstrohm AC, Albrecht TR, Suñé C, Bedford MT, Garcia-Blanco MA (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933Freely accessible. PMID 11604498. 

Further reading[edit]