SFRP2

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SFRP2
Identifiers
Aliases SFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDs MGI: 108078 HomoloGene: 56438 GeneCards: SFRP2
RNA expression pattern
PBB GE SFRP2 gnf1h04341 s at fs.png

PBB GE SFRP2 gnf1h07261 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003013

NM_009144

RefSeq (protein)

NP_003004

NP_033170

Location (UCSC) Chr 4: 153.78 – 153.79 Mb Chr 3: 83.77 – 83.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.[3][4]

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. PMC 28358Freely accessible. PMID 9391078. doi:10.1073/pnas.94.25.13636. 
  4. ^ a b "Entrez Gene: SFRP2 secreted frizzled-related protein 2". 

Further reading[edit]