From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
Symbols SGCA ; 50-DAG; A2; ADL; DAG2; DMDA2; LGMD2D; SCARMD1; adhalin
External IDs OMIM600119 MGI894698 HomoloGene9 GeneCards: SGCA Gene
Species Human Mouse
Entrez 6442 20391
Ensembl ENSG00000108823 ENSMUSG00000001508
UniProt Q16586 P82350
RefSeq (mRNA) NM_000023 NM_009161
RefSeq (protein) NP_000014 NP_033187
Location (UCSC) Chr 17:
50.16 – 50.18 Mb
Chr 11:
94.96 – 94.98 Mb
PubMed search [1] [2]

Alpha-sarcoglycan is a protein that in humans is encoded by the SGCA gene.[1][2]

The dystrophin-glycoprotein complex (DGC) comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Components of the DGC include dystrophin (MIM 300377), which is deficient in Duchenne muscular dystrophy (DMD; MIM 310200); syntrophins (e.g., MIM 600026); dystroglycans (MIM 128239); and sarcoglycans, such as adhalin, a 50-kD transmembrane protein (Roberds et al., 1993).[supplied by OMIM][2]


SGCA has been shown to interact with Biglycan.[3]


Further reading[edit]

External links[edit]