The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix.
Zeta-sarcoglycan is reduced in mouse models of muscular dystrophy and SGCZ is found as a component of the vascular smooth muscle sarcoglycan complex. Hence SGCZ may be important in the pathogenesis of muscular dystrophy.
^ abWheeler MT, Zarnegar S, McNally EM (September 2002). "Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy". Hum. Mol. Genet.11 (18): 2147–54. doi:10.1093/hmg/11.18.2147. PMID12189167.
Anastasi G, Cutroneo G, Sidoti A et al. (2007). "Sarcoglycan subcomplex expression in normal human smooth muscle.". J. Histochem. Cytochem.55 (8): 831–43. doi:10.1369/jhc.6A7145.2007. PMID17438352.CS1 maint: Explicit use of et al. (link)