SH2B2

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SH2B2
Protein SH2B2 PDB 1q2h.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SH2B2, APS, SH2B adaptor protein 2
External IDs MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020979

NM_018825
NM_001302938
NM_001302939

RefSeq (protein)

NP_066189

Location (UCSC) Chr 7: 102.29 – 102.32 Mb Chr 5: 136.22 – 136.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[3][4]

Function[edit]

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[4]

Interactions[edit]

SH2B2 has been shown to interact with TrkA[5] and Cbl gene.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi:10.1038/sj.onc.1201163. PMID 9233773. 
  4. ^ a b "Entrez Gene: SH2B2 SH2B adaptor protein 2". 
  5. ^ Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458. 
  6. ^ Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881. 
  7. ^ Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755Freely accessible. PMID 18273061. 

Further reading[edit]