SH2B2

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SH2B2
Protein SH2B2 PDB 1q2h.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSH2B2, APS, SH2B adaptor protein 2
External IDsOMIM: 605300 MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SH2B2
Genomic location for SH2B2
Band7q22.1Start102,285,091 bp[1]
End102,321,711 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020979
NM_001359228
NM_001359229
NM_001359230
NM_001359231

NM_018825
NM_001302938
NM_001302939

RefSeq (protein)

NP_066189
NP_001346157
NP_001346158
NP_001346159
NP_001346160

NP_001289867
NP_001289868
NP_061295

Location (UCSC)Chr 7: 102.29 – 102.32 MbChr 5: 136.22 – 136.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[5][6]

Function[edit]

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[6]

Interactions[edit]

SH2B2 has been shown to interact with TrkA[7] and Cbl gene.[8][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160999 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005057 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi:10.1038/sj.onc.1201163. PMID 9233773.
  6. ^ a b "Entrez Gene: SH2B2 SH2B adaptor protein 2".
  7. ^ Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458.
  8. ^ Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881.
  9. ^ Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.

Further reading[edit]