SH2D1B

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SH2D1B
Identifiers
Aliases SH2D1B, EAT2, SH2 domain containing 1B
External IDs MGI: 1349420 HomoloGene: 8070 GeneCards: SH2D1B
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_053282

NM_012009

RefSeq (protein)

NP_444512

n/a

Location (UCSC) Chr 1: 162.4 – 162.41 Mb Chr 1: 170.28 – 170.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.[3][4][5]

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM][5]

Interactions[edit]

SH2D1B has been shown to interact with SLAMF1.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene. 13 (12): 2649–58. PMID 9000139. 
  4. ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701Freely accessible. PMID 11689425. 
  5. ^ a b "Entrez Gene: SH2D1B SH2 domain containing 1B". 

Further reading[edit]